Chronic gastritis can lead to macrocytic anemia due to:

Question

BlackTom AI · Accepted Answer

Question restatement: The prompt asks which factor in chronic gastritis can lead to macrocytic anemia.
Option 1: 'Increased gastric acid production' — This is unlikely to be the cause of macrocytic anemia. Chronic gastritis often reduces or dysregulates acid secretion, and high acid is not the driver of macrocytosis.
Option 2: 'Loss of intrinsic factor and vitamin B12 malabsorption' — This is the correct mechanism. Chronic gastritis, especially autoimmune types like pernicious anemia, can destroy gastric parietal cells or otherwise impair intrinsic factor production. Without intrinsic factor, vitamin B12 cannot be efficiently absorbed in the ileum, leading to vitamin B12 deficiency and macrocytic (megaloblastic) anemia due to impaired DNA synthesis in developing red blood cells.
Option 3: 'Decreased iron absorption' — While iron deficiency causes microcytic anemia, not macrocytic. Decreased iron absorption would lead to small, pale red cells, not the enlarged macrocytes characteristic of B12 deficiency.
Option 4: 'Folate toxicity' — Folate toxicity is not a recognized mechanism linking chronic gastritis to macrocytic anemia. Folate status affects micro/macrocytosis, but toxicity itself does not cause macrocytosis and is not driven by gastritis pathology. Folate deficiency can cause macrocytosis, but the statement asserts toxicity, which is incorrect and clinically irrelevant here.

11:709:483:01 MNT I NUTR ASSESS Midterm

Chronic gastritis can lead to macrocytic anemia due to:

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