Vesicles that travel in a Retrograde manner move from the cis-Golgi to the endoplasmic reticulum (ER), while vesicles that travel in a Anterograde manner move from the ER to the cis-Golgi.

Question

BlackTom AI · Accepted Answer

To tackle this question, we first restate the pathway directions described: vesicles traveling in a Retrograde manner are said to move from the cis-Golgi to the endoplasmic reticulum (ER), while vesicles traveling in an Anterograde manner move from the ER to the cis-Golgi.

Option: Retrograde
Explanation: The term retrograde refers to movement backward along the secretory pathway. In standard cell biology, vesicles that travel from the Golgi apparatus back to the ER are considered retrograde transport. Specifically, vesicles often bud from the Golgi and return ER-resident proteins and materials back to the ER, helping to recycle components and maintain proper compartmental organization. In this context, moving from the cis-Golgi toward the ER matches the retrograde direction, so this option correctly describes that directionality.

Option: Anterograde
Explanation: Anterograde transport denotes forward movement along the secretory pathway, from the ER toward the Golgi complex and onward to later destinations. In this question, the described forward route is from the ER to the cis-Golgi, which aligns with anterograde transport. This option correctly captures the forward, not backward, flow of vesicular traffic.

Common clarifications and misconceptions:
- Some learners confuse the terms by thinking all Golgi-to-ER movement is lysosomal or non-specific; in reality, retrograde transport is a defined, COPI-coated vesicle process that recycles proteins back to the ER.
- Others may think that ER-to-Golgi transport is bidirectional or that cargo cannot move backward; however, established models distinguish retrograde (Golgi to ER) from anterograde (ER to Golgi and beyond).
- If a question asks for a single term describing ER-to-Golgi movement, that term is anterograde; if it asks for Golgi-to-ER movement, the correct term is retrograde.

In summary, the two terms map onto distinct directions of vesicular traffic: Retrograde correctly describes cis-Golgi to ER movement, and Anterograde correctly describes ER to cis-Golgi movement.

BIOT5750.39480.202530 Module 10 Quiz S25

Vesicles that travel in a Retrograde manner move from the cis-Golgi to the endoplasmic reticulum (ER), while vesicles that travel in a Anterograde manner move from the ER to the cis-Golgi.

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