Which of the following statements is NOT true about T1D?

Question

BlackTom AI · Accepted Answer

Question restatement: Which of the following statements is NOT true about T1D?
Option a: 'It usually leads to insulin resistance.'
Analysis of option a: Type 1 diabetes is characterized by autoimmune destruction of pancreatic beta cells, which leads to an absolute deficiency of insulin. This causes hypoinsulinemia and hyperglycemia, not insulin resistance. Insulin resistance is more commonly associated with Type 2 diabetes, obesity, and metabolic syndrome. Therefore, the claim that T1D usually leads to insulin resistance is incorrect.
Context clarification: In T1D, the body cannot produce enough insulin at all, which is a fundamental distinction from insulin resistance where the body’s cells do not respond effectively to insulin despite its presence. This distinction helps explain why treatment for T1D centers on insulin replacement, whereas managing insulin resistance often involves lifestyle changes and medications that improve insulin sensitivity.
Why this statement is misleading: It conflates two different pathogenic mechanisms. Insulin resistance implies impaired glucose uptake due to cellular response, while T1D primarily involves a lack of insulin production rather than a failure of response. The overall metabolic profile of T1D patients is driven by deficient insulin action, not resistance to insulin.
If there were other options: For completeness, one would evaluate each alternate statement against established descriptions of T1D (autoimmune beta-cell destruction, lack of endogenous insulin, dependence on exogenous insulin, typically normal or low insulin sensitivity early in disease but not a defining feature). However, with the given single option, the key takeaway is that this statement does not align with the pathophysiology of Type 1 diabetes.

Which of the following statements is NOT true about T1D?

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