Type 1 diabetes is caused primarily by autoimmunity targeting pancreatic alpha cells, leading to impaired glucagon secretion.

Question

Type 1 diabetes is caused primarily by autoimmunity targeting pancreatic alpha cells, leading to impaired glucagon secretion.

BlackTom AI · Accepted Answer

The question presents a statement about Type 1 diabetes and asks us to judge its truthfulness.
Option a) 'True' would assert that Type 1 diabetes is caused primarily by autoimmunity targeting pancreatic alpha cells, leading to impaired glucagon secretion. In reality, the autoimmune attack in Type 1 diabetes predominantly targets pancreatic beta cells, which are responsible for insulin production. This distinction is crucial because the loss of beta cells leads to insulin deficiency, not a primary impairment of glucagon secretion from alpha cells. 
Option b) 'False' would indicate that the statement is not accurate. This is consistent with current medical understanding: Type 1 diabetes is characterized by autoimmune destruction of beta cells, resulting in insufficient insulin, while alpha cell function and glucagon dynamics are not the central pathogenic feature described in this option. While glucagon physiology can be affected in various diabetes contexts, the core claim about alpha-cell targeting and impaired glucagon secretion does not describe the mechanism of Type 1 diabetes. 
To recap, option a misidentifies the cell type targeted (beta vs alpha) and the primary consequence (insulin deficiency vs impaired glucagon), whereas option b correctly identifies that the statement as given is not an accurate description of Type 1 diabetes. The essential takeaway is the beta-cell autoimmune destruction drives Type 1 diabetes rather than autoimmunity against alpha cells with glucagon cessation.

Type 1 diabetes is caused primarily by autoimmunity targeting pancreatic alpha cells, leading to impaired glucagon secretion.

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