题目
题目

PUBHP6040_001_2025_3 - DETERMINANTS OF HEALTH 2025 Week 9 - Learning Check

多项选择题

In calculating a Reference dose (RfD) for a chemical, uncertainty factors are considered. Which of the following statements are true?

选项
A.An example of an uncertainty factor would be that we only have animal data and lack human data.
B.That the target tissue of the chemical is not fully understood would also be considered an uncertainty factor.
C.Another uncertainty factor would be if we do not know the solubility of the chemical.
D.To account for individual susceptibility/sensitivity, divide the NOAEL by 10.
E.To account for individual susceptibility/sensitivity, divide the NOAEL by 10.
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标准答案
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思路分析
When evaluating how uncertainty factors (UFs) contribute to calculating a Reference Dose (RfD), it's helpful to map each statement to common concepts in toxicology risk assessment. Option 1: 'An example of an uncertainty factor would be that we only have animal data and lack human data.' This is accurate. Interspecies extrapolation, from animals to humans, is a primary reason for applying an uncertainty factor to account for potential differences in sensitivity and biology betwe......Login to view full explanation

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