Which of the following statements about the plasticity of synapses in the mammalian CNS is false?

Question

BlackTom AI · Accepted Answer

Looking at the topic of synaptic plasticity in the mammalian CNS, each statement needs careful evaluation.
Option 1: 'In some forms of synaptic plasticity calcium ions play a central role.' This is accurate, because calcium influx through NMDA receptors or voltage-gated calcium channels is a key trigger for many forms of plasticity, including enduring changes in synaptic strength. The calcium signal often activates intracellular pathways that lead to LTP or other modifications.
Option 2: 'The strength of synaptic connections is always increased in both short-term and long-term synaptic plasticity.' This claim is misleading and false, since synaptic plasticity encompasses both potentiation (strengthening) and depression (weakening). Short-term plasticity can show facilitation or depression, and long-term plasticity includes both LTP (increase) and LTD (decrease). The word 'always' makes the statement incorrect because not all forms result in an increased strength, and not all time scales yield potentiation.
Option 3: 'Synaptic efficacy can be adjusted by changes in the amount of neurotransmitter that is released.' This is true. Modifications in release probability or the amount of neurotransmitter released (quantal content) are established mechanisms to alter synaptic efficacy, independent of postsynaptic receptor changes.
Option 4: 'Changes in synaptic efficacy can occur over different time scales ranging from milliseconds to years.' This is correct, as synaptic modifications can be rapid (milliseconds) through short-term plasticity or extend to long-lasting changes over hours to years, reflecting diverse underlying mechanisms.

NEUR20001_2025_SM2 Assessment for Workshop 9 - neural plasticity and glia

Which of the following statements about the plasticity of synapses in the mammalian CNS is false?

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NEUR20001_2025_SM2 Assessment for Workshop 9 - neural plasticity and glia

Which of the following statements about the plasticity of synapses in the mammalian CNS is false?

查看解析

登录即可查看完整答案

类似问题

What is the effect of the Stau2 protein?

In Aplysia, long-term sensitisation differs from short-term sensitisation primarily because it:

Which statement best describes spike-timing–dependent plasticity (STDP) and its primary cellular mechanism?

Which of the following best characterizes the canonical mechanism of NMDA receptor–dependent long-term depression (LTD) in hippocampal CA1 neurons?

In the context of short-term plasticity what causes facilitation?

Which of the following adaptations is most likely in a cholinergic synapse in which there is progressive degeneration of the presynaptic terminal?

Long-term potentiation is associated with the movement of ________ to the _______.

Long term potentiation refers to

更多留学生实用工具

希望你的学习变得更简单

Long-term potentiation is associated with the movement of __ to the _.