The true adult stem cell of the mammalian intestinal stem cell crypt is the Paneth cell that expresses LGR5.

Question

BlackTom AI · Accepted Answer

The question presents a statement about the true adult stem cell population in the mammalian intestinal crypt and asks whether it is a Paneth cell expressing LGR5.
Option 1: True. This claim asserts that Paneth cells, which reside at the base of the crypts and are known for their secretion of antimicrobial components, are the true adult stem cells and that they express LGR5. In fact, this is incorrect because the canonical adult intestinal stem cells are LGR5+ crypt base columnar (CBC) cells, not Paneth cells. Paneth cells are post-mmitotic, differentiated secretory cells that form part of the niche and help support stem cells through signaling, but they are not themselves the stem cells. Therefore, labeling Paneth cells as the true stem cells with LGR5 expression misidentifies the cell type responsible for long-term self-renewal.
Option 2: False. This choice correctly rejects the idea that Paneth cells are the true adult stem cells expressing LGR5. The accurate view is that LGR5 marks the actively cycling stem cells located at the crypt base (CBCs), which give rise to all differentiated lineages of the intestinal epithelium. Paneth cells, while important for providing a niche and producing antimicrobial factors, are differentiated cells and do not serve as the primary LGR5+ stem cell population. The emphasis is on the distinction between stem cells (LGR5+ CBCs) and niche-supporting differentiated cells (Paneth cells).
The overall concept hinges on identifying stem cells by their characteristic markers and functional role: LGR5+ CBCs are stem cells, whereas Paneth cells are specialized secretory cells that support the stem cell niche but are not themselves the stem cells slated for continuous renewal.

The true adult stem cell of the mammalian intestinal stem cell crypt is the Paneth cell that expresses LGR5.

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