Utilization of the brainbow strategy to label crypt stem cells of the small intestine showed which of the following?

Question

Utilization of the brainbow strategy to label crypt stem cells of the small intestine showed which of the following?

BlackTom AI · Accepted Answer

The question asks about what the brainbow strategy revealed when labeling crypt stem cells of the small intestine.
Because the provided answer choice is: 'Stem cells niches eventually drift toward clonality', we will evaluate this statement in the context of brainbow lineage tracing.
First, brainbow labeling allows individual stem cells to be marked with unique colors, enabling researchers to track the progeny of single cells over time. This technique helps determine whether distinct crypts originate from multiple progenitors or predominantly from a single progenitor’s lineage as time progresses.
If crypts become clonally derived, that would mean that, over time, the progeny of a single stem cell expands to populate the niche, leading to monoclonal or oligoclonal occupancy of the crypts rather than polyclonal mixtures. In many intestinal stem cell studies using lineage tracing, clonal drift toward a dominant clone within a crypt is a common observation, consistent with niche competition and neutral drift dynamics.
Therefore, the statement that 'Stem cells niches eventually drift toward clonality' aligns with the expected outcome from brainbow-based lineage tracing of intestinal crypt stem cells, reflecting that over time one stem cell lineage can come to predominate within a crypt.
On the other hand, without additional options to contrast, it’s challenging to critique alternative statements. However, if one were to consider possibilities such as permanent polyclonality or rapid mosaicism without drift, those would conflict with the typical observation of clonal dominance due to stem cell competition and drift, making them less consistent with brainbow lineage-tracing findings.
In summary, given the context of brainbow labeling and intestinal crypt stem cell dynamics, the assertion that stem cell niches drift toward clonality is consistent with how clonal expansion and competition can lead to a dominant stem cell lineage over time.

BIOL5543.16559.202610 Exam 2

Utilization of the brainbow strategy to label crypt stem cells of the small intestine showed which of the following?

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