Question at position 55 Which of the following is NOT a function of angiotensin II?Stimulating the adrenal cortex to release aldosteroneDirectly stimulating renin secretion from the kidneysStimulating the posterior pituitary to release ADHIncreasing vasoconstriction to raise blood pressure

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BlackTom AI · Accepted Answer

Consider the roles attributed to angiotensin II in regulating blood pressure and fluid balance. 
Option 1: 'Stimulating the adrenal cortex to release aldosterone' is a well-established function. Ang II stimulates the zona glomerulosa of the adrenal cortex to secrete aldosterone, which promotes sodium and water retention and helps raise blood pressure. This statement is true.
Option 2: 'Directly stimulating renin secretion from the kidneys' is not correct. In fact, angiotensin II participates in a negative feedback loop that inhibits renin release from juxtaglomerular cells. Renin release is typically stimulated by low blood pressure, sympathetic activity, or low filtrate sodium, not by Ang II itself; Ang II does not directly stimulate renin secretion. This statement is false.
Option 3: 'Stimulating the posterior pituitary to release ADH' aligns with known physiology. Ang II can promote release of antidiuretic hormone (ADH, vasopressin) from the posterior pituitary, contributing to water retention and vasoconstriction. This statement is true.
Option 4: 'Increasing vasoconstriction to raise blood pressure' is a core action of angiotensin II. It directly causes vasoconstriction of efferent and sometimes arterial vessels, raising systemic vascular resistance and blood pressure. This statement is true.
In summary, each option reflects or contradicts aspects of angiotensin II physiology. The only incorrect claim is that Ang II directly stimulates renin secretion from the kidneys, which is contrary to its role in negative feedback and renin regulation. Therefore, option 2 is the statement that is NOT a function of angiotensin II.

Question at position 55 Which of the following is NOT a function of angiotensin II?Stimulating the adrenal cortex to release aldosteroneDirectly stimulating renin secretion from the kidneysStimulating the posterior pituitary to release ADHIncreasing vasoconstriction to raise blood pressure

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