Question at position 13 Which organ is primarily responsible for the conversion of angiotensin I to angiotensin II?KidneysHeartLungsAdrenal glandsLiver

Question

BlackTom AI · Accepted Answer

The question asks which organ mainly converts angiotensin I to angiotensin II. Think about the biochemical pathway of the renin-angiotensin system and where the key enzymatic step occurs.
Option 1: Kidneys — While the kidneys release renin which initiates the pathway, they are not the site where angiotensin I is converted to angiotensin II. This option is incorrect because renin acts upstream to generate angiotensin I, not to convert it to II.
Option 2: Heart — The heart is not the primary site of conversion for angiotensin I to angiotensin II. It participates in cardiovascular regulation, but not in this specific enzymatic step. This makes the option inaccurate.
Option 3: Lungs — This is the correct choice. Angiotensin-converting enzyme (ACE), which converts angiotensin I to angiotensin II, is highly expressed in the pulmonary endothelium of the lungs, making the lungs the main site for this conversion.
Option 4: Adrenal glands — The adrenal glands respond to angiotensin II to release aldosterone, but they are not the site where angiotensin I is converted to II. This option confuses downstream hormonal response with the enzymatic conversion step.
Option 5: Liver — The liver plays a role in producing angiotensinogen, the precursor to angiotensin I, but it is not where angiotensin I is converted to angiotensin II. Thus, this option is not correct for the conversion step.
In summary, the conversion of angiotensin I to angiotensin II is mediated by ACE in the lungs, which makes the lungs the correct answer, while the other organs are involved in different parts of the renin-angiotensin system or related processes but not this specific conversion.

Question at position 13 Which organ is primarily responsible for the conversion of angiotensin I to angiotensin II?KidneysHeartLungsAdrenal glandsLiver

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