The most likely mechanisms responsible for renal excretion of intact paracetamol are:[Fill in the blank]

Question

BlackTom AI · Accepted Answer

The question asks about the renal excretion mechanism for intact paracetamol and provides four choices. 
Option a: Filtration. Filtration refers to the movement of small molecules from glomerular plasma into Bowman's space. Paracetamol is a relatively small molecule, so it can be filtered. However, filtration alone does not account for what happens to the molecule after filtration; if the drug is reabsorbed or secreted, those processes also shape the final amount excreted as intact drug. Thus, selecting filtration only would ignore possible post-filtration handling.
Option b: Filtration plus reabsorption. This option recognizes that paracetamol is filtered at the glomerulus, and a portion of the filtered drug can be reabsorbed along the renal tubules back into the bloodstream. Since paracetamol is relatively polar but not highly ionized at physiological pH, some of it may be reabsorbed passively, leading to excretion of a portion as intact drug. The balance between filtration and passive reabsorption is consistent with typical renal handling of small, relatively lipophilic or moderately lipophilic compounds that are not fully ionized.
Option c: Filtration plus secretion. Secretion would involve active transport of the drug from the peritubular capillaries into the tubular lumen via transporters. For paracetamol, there is limited evidence of a significant active secretory pathway for intact molecule in the nephron compared to filtration and reabsorption. While some drugs are secreted, in the case of intact paracetamol, the dominant mechanisms described in pharmacokinetics are filtration followed by partial reabsorption, rather than a major secretion process.
Option d: Reabsorption only. If excretion of intact paracetamol were solely due to reabsorption, there would be no net loss to urine beyond what was reabsorbed, which contradicts the concept of renal excretion of a portion of the filtered drug. A reabsorption-only explanation ignores the initial filtration step that introduces drug into the tubular lumen and thus cannot account for renal elimination as a fraction of the drug.
In summary, the most comprehensive and accurate description among the choices acknowledges that paracetamol is filtered and then partly reabsorbed along the tubules, shaping its renal excretion profile. The other options omit essential steps or overstate a single process, leading to an incomplete or incorrect portrayal of renal handling of intact paracetamol.

The most likely mechanisms responsible for renal excretion of intact paracetamol are:[Fill in the blank]

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