Question at position 58 Renal clearance is increased by which of the following?Increased tubular secretionDecreased GFRIncreased reabsorption and decreased secretionIncreased tubular reabsorption

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BlackTom AI · Accepted Answer

The question asks which change would lead to increased renal clearance.
Option 1: Increased tubular secretion. This adds more substance from the blood into the tubular lumen, enhancing the amount eliminated in urine, thereby increasing clearance. This is a correct mechanism for raising clearance of substances that can be secreted.
Option 2: Decreased GFR. Since glomerular filtration is the primary route for many solutes to enter the filtrate, a decrease in GFR reduces the amount filtered and thus typically lowers clearance, making this option incorrect.
Option 3: Increased reabsorption and decreased secretion. Reabsorption pulls solutes from the tubular lumen back into the bloodstream, reducing urinary excretion. This would decrease, not increase, overall clearance.
Option 4: Increased tubular reabsorption. Similar to option 3, more solute is reabsorbed rather than excreted, leading to reduced clearance. This makes it incorrect as well.
In summary, among the options provided, only increasing tubular secretion raises the amount of solute eliminated in urine, thereby increasing renal clearance.

Question at position 58 Renal clearance is increased by which of the following?Increased tubular secretionDecreased GFRIncreased reabsorption and decreased secretionIncreased tubular reabsorption

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