Question at position 31 What effect does increased tubular secretion have on renal clearance?Increases renal clearanceReduces urine productionHas no effect on renal clearanceIncreased plasma volumeDecreases renal clearance

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Question: What effect does increased tubular secretion have on renal clearance?

Option 1: Increases renal clearance
Explanation: Tubular secretion adds solutes from the peritubular capillaries into the tubular lumen, augmenting the amount of substance eliminated in urine. For substances that are secreted, increased secretion directly raises their clearance because more of the substance is removed per unit time. This aligns with renal physiology where clearance can be enhanced by secretion in addition to glomerular filtration.

Option 2: Reduces urine production
Explanation: While secretion can influence the composition of urine, it does not inherently imply a reduction in urine volume. Urine production (diuresis) is governed by glomerular filtration rate, tubular reabsorption, and overall fluid balance. Secretion per se does not automatically decrease urine volume.

Option 3: Has no effect on renal clearance
Explanation: This would be incorrect because tubular secretion is a recognized mechanism that contributes to renal clearance. If secretion increases, the amount of solute cleared per unit time increases, thereby increasing clearance.

Option 4: Increased plasma volume
Explanation: An increase in plasma volume can influence filtration and overall kidney hemodynamics, potentially affecting glomerular filtration rate indirectly. However, the question is specifically about tubular secretion’s impact on clearance, not systemic volume status. This option introduces a separate factor and does not describe the direct effect of secretion on clearance.

Option 5: Decreases renal clearance
Explanation: This is the opposite of what tubular secretion does. If secretion increases, clearance tends to increase rather than decrease. The notion of decreased clearance contradicts the mechanism of secretion into the tubular lumen.

Question at position 31 What effect does increased tubular secretion have on renal clearance?Increases renal clearanceReduces urine productionHas no effect on renal clearanceIncreased plasma volumeDecreases renal clearance

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