What type of interaction does GLU86 form with the ligand?

Question

BlackTom AI · Accepted Answer

The question asks: What type of interaction does GLU86 form with the ligand? Since the answer options are not provided in the data, we only have the given answer: Hydrogen bond.

To evaluate this, consider the chemistry of GLU (glutamate): the side chain ends with a carboxylate group (COO− at physiological pH). This moiety is a versatile participant in noncovalent interactions. It can act as a hydrogen-bond acceptor via its carbonyl oxygens for hydrogen-bond donors present on the ligand. When a ligand has N–H, O–H, or similar hydrogen-bond donor groups, a hydrogen-bond interaction with GLU86 is a common and plausible form of stabilization in protein–ligand interfaces.

In more detail:
- Hydrogen bonds are directional and often involve a hydrogen donor (e.g., –NH or –OH) on the ligand and an acceptor (the carboxylate oxygens) on GLU86.
- The carboxylate can also participate in ionic interactions (electrostatic salt bridges) with positively charged ligand moieties, but these are not hydrogen bonds per se. If the ligand carries a protonated amine or other cationic group, there could be an additional ionic component; however, the hydrogen-bond framework remains a key and frequent interaction for GLU residues.
- Because the question states GLU86 “forms with the ligand” and the provided answer is Hydrogen bond, this aligns with the typical role of a glutamate side chain as a hydrogen-bond acceptor in many protein–ligand complexes.

Potential alternative interpretations (in absence of options):
- If the ligand presented a strong positive charge, there could be ionic interactions or salt bridges with GLU86, which would be different from a hydrogen bond and often stronger under certain conditions.
- Covalent bonding is unlikely for a standard protein–ligand interaction at a single residue like GLU86 in most non-covalent docking contexts.

In summary, given standard protein–ligand chemistry, GLU86 most plausibly forms hydrogen bonds with ligand donors via its carboxylate oxygens, making Hydrogen bond a reasonable and common interaction type for this residue–ligand pair.

2254 BIOSC 1544 SEC1000 Homework: BINANA

What type of interaction does GLU86 form with the ligand?

查看解析

登录即可查看完整答案

类似问题

Load the 1XDN files (receptor.pdb and ligand.pdb) into BINANA to answer this and the following questions. What type of interaction does ASN92 form with the ligand?

What type of interaction does LEU83 form with the ligand?

What type of interaction does GLU81 form with the ligand?

What type of interactions does ARG309 form with the ligand?

For this and the next two questions, consider the protein/ligand structure: https://durrantlab.pitt.edu/apps/molmoda/beta/?load=5YAV Which of the following amino-acid residues form hydrophobic contacts with the small-molecule ligand?

How would you describe the interaction between Lys167 and the ligand?

In a consumer society, many adults channel creativity into buying things

Economic stress and unpredictable times have resulted in a booming industry for self-help products

更多留学生实用工具

考试浏览器助手

风格化写作助手

论文查重助手

文献引用助手

课堂转译助手

课堂笔记助手

Quiz搜索助手

学校历年真题

智能刷题助手

智能匹配练习

希望你的学习变得更简单