Tim is prescribed the small molecule inhibitor bortezomib to treat multiple myeloma. Based on the “-zomib” suffix of the drug’s name, bortezomib is most likely a:

Question

Tim is prescribed the small molecule inhibitor bortezomib to treat multiple myeloma. Based on the “-zomib” suffix of the drug’s name, bortezomib is most likely a:

BlackTom AI · Accepted Answer

The question asks us to interpret the meaning of the suffix "-zomib" in the context of a drug name used to treat multiple myeloma.
Option a) PARP inhibitor: PARP inhibitors are a class of drugs that target poly (ADP-ribose) polymerase enzymes and are often used in cancers with BRCA mutations. They are typically named with suffixes like "-parib" (e.g., olaparib, niraparib), not "-zomib". This option mislabels the common naming convention for PARP inhibitors, making it unlikely based on the suffix clue.
Option b) Tyrosine kinase inhibitor: Tyrosine kinase inhibitors (TKIs) include drugs such as imatinib or erlotinib. Their names frequently end in "-nib" rather than "-zomib". While both endings end in "-ib" sounds, the specific "-zomib" pattern is not associated with TKIs, so this choice conflicts with the naming convention suggested by the question.
Option c) CDK inhibitor: CDK inhibitors, used in various cancers, are commonly named with endings like "-nib" as well (e.g., palbociclib). They are not typically recognized by the suffix "-zomib". This makes this option unlikely when considering the suffix cue provided.
Option d) Proteasome inhibitor: Drugs with the suffix "-zomib" are well known to include proteasome inhibitors used in multiple myeloma, such as bortezomib and carfilzomib. The characteristic naming pattern here aligns with proteasome inhibition and with the clinical context of multiple myeloma, which strengthens this option as the correct association with the suffix clue.
In terms of reasoning about the underlying pharmacology, proteasome inhibitors disrupt the proteasome-mediated degradation of intracellular proteins, leading to accumulation of misfolded or regulatory proteins and inducing apoptosis in myeloma cells. The other classes listed — PARP inhibitors, TKIs, and CDK inhibitors — have distinct targets and are typically identified by different naming conventions, and their mechanisms do not align with the specific suffix clue provided in the question.
Putting the pieces together, the suffix clue points toward a proteasome-targeting agent, while the other options mismatch both the naming convention and the intended pharmacological category. This alignment between the suffix and the drug class in option d explains why this option is the best fit given the stem and context.

Tim is prescribed the small molecule inhibitor bortezomib to treat multiple myeloma. Based on the “-zomib” suffix of the drug’s name, bortezomib is most likely a:

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