Which factor is NOT typically influenced by genetic variations in pharmacogenomics?

Question

BlackTom AI · Accepted Answer

To approach this question, consider what pharmacogenomics studies: how genetic differences influence drug behavior and patient outcomes. 
Option 1: Time of day the drug is administered. This is largely governed by circadian rhythms, dosing schedules, and practical considerations like meals or adherence, rather than genetic variation. While timing can affect drug exposure in some contexts, pharmacogenomics does not typically describe genetic influence on when to take a medication.
Option 2: Drug dosage requirements. Genetic differences in enzymes (such as CYP450 variants) or transporters can alter how quickly a drug is metabolized or distributed, leading to higher or lower dose needs for therapeutic effect. This is a classic area of pharmacogenomics, and is commonly observed in clinical practice.
Option 3: Drug safety and adverse reactions. Genetic factors can predispose individuals to adverse events, such as HLA alleles associated with hypersensitivity reactions or metabolic defects that increase toxicity risk. This is a well-established facet of pharmacogenomics.
Option 4: Drug efficacy and response. Genetic variation can influence receptor binding, signaling pathways, or metabolite levels, affecting how well a drug works for a given patient. Variability in efficacy due to genetics is a central theme in pharmacogenomics.
In summary, options 2, 3, and 4 describe typical pharmacogenomic influences on dosage, safety, and efficacy, while option 1 describes a timing factor more related to external or physiological rhythms than genetics. Therefore, the statement that is NOT typically influenced by genetic variations is the time-of-day administration.

PCOL2021 2025 Practice MCQ Section A - 2025

Which factor is NOT typically influenced by genetic variations in pharmacogenomics?

查看解析

登录即可查看完整答案

类似问题

Evaluate the implications of pharmacogenomic variations in metabolizing enzymes when designing a clinical trial for a new cardiovascular drug.

How can genetic variation in HLA antigens influence drug therapy outcomes?

When considering the variability of drug metabolism among different geographical ancestries, which factor is most relevant for optimizing patient-specific therapy?

In evaluating a patient’s CYP2D6 phenotype before prescribing a drug with a narrow therapeutic window, which of the following represents the most critical clinical concerns?

Evaluate the importance of integrating pharmacogenomic considerations into global drug development strategies.

What role do drug transporters play in pharmacogenomics?

In a consumer society, many adults channel creativity into buying things

更多留学生实用工具

考试浏览器助手

风格化写作助手

论文查重助手

文献引用助手

课堂转译助手

课堂笔记助手

Quiz搜索助手

学校历年真题

智能刷题助手

智能匹配练习

希望你的学习变得更简单