All the following are mechanisms of action that have been implicated in Parkinson’s Disease EXCEPT:

Question

BlackTom AI · Accepted Answer

Let's break down each option in the context of Parkinson’s Disease (PD) mechanisms.
Option 1: Microglial activation. Neuroinflammation and microglial activation have been repeatedly implicated in PD, contributing to oxidative stress and neuronal degeneration via cytokine release and a pro-inflammatory environment. This is a well-supported mechanism in PD pathology.
Option 2: Parkin aggregation. Parkin is an E3 ubiquitin ligase involved in tagging damaged mitochondria for degradation (mitophagy). PD is associated with Parkin loss-of-function mutations and deficits in Parkin-mediated mitophagy, but aggregation of Parkin itself is not a commonly recognized pathogenic mechanism in PD. Thus, this option is less supported as a mechanism compared to the others listed.
Option 3: Lysosomal autophagy. Defects in lysosomal autophagy and related pathways (e.g., GBA mutations affecting glucocerebrosidase) are linked to PD, leading to accumulation of misfolded proteins and cellular stress. Impaired autophagy is a widely discussed mechanism in PD.
Option 4: Alpha-synuclein aggregation. The hallmark of PD is alpha-synuclein aggregation into Lewy bodies and Lewy neurites. This is a central, well-established pathogenic mechanism in PD.
Option 5: Mitochondrial dysfunction. Mitochondrial impairments, including complex I dysfunction and impaired mitophagy, are consistently associated with PD and are thought to contribute to dopaminergic neuron vulnerability.
In summary, all listed mechanisms except Parkin aggregation have strong, ongoing support in PD pathology literature. Microglial activation, lysosomal autophagy defects, alpha-synuclein aggregation, and mitochondrial dysfunction each have clear connections to disease mechanisms, whereas Parkin aggregation is not commonly described as a pathogenic mechanism of PD.

01:146:447:01 CLINICAL NEUROBIO CN F25 Exam 3

All the following are mechanisms of action that have been implicated in Parkinson’s Disease EXCEPT:

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01:146:447:01 CLINICAL NEUROBIO CN F25 Exam 3

All the following are mechanisms of action that have been implicated in Parkinson’s Disease EXCEPT:

查看解析

登录即可查看完整答案

类似问题

How did Mikael Rydberg describe the state of his Parkinson's Disease ~8 years after receiving fetal mesencephalic progenitor transplants. His disease

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Question at position 7 Which of these would you find in an individual with Parkinson's disease?Slow breathing, poor balanceTics, seizuresTremors, rigidity, shuffling gaitHyperreflexia, poor balance, hoarse voice

Pathological changes in a typical Parkinson disease patient includes:

Which of the following statements about Parkinson’s disease is FALSE?

Parkinson's can be easy to spot because:

In the frozen addicts (movie), the addicts developed _____ from taking ____

Ralph has been demonstrating symptoms of Parkinson's disease (such as hand tremors). The deterioration of neurons using _____________ is most linked to Parkinson's disease in the brain area called _____________.

更多留学生实用工具

希望你的学习变得更简单

Pathological changes in a typical Parkinson disease patient includes: 

In the frozen addicts (movie), the addicts developed _ from taking

Ralph has been demonstrating symptoms of Parkinson's disease (such as hand tremors). The deterioration of neurons using _ is most linked to Parkinson's disease in the brain area called _.