You are designing a clinical trial to modulate chronic pain circuits. Which cortical target is most promising based on evidence from both mouse and human studies?

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BlackTom AI · Accepted Answer

The prompt asks us to identify which cortical target is most promising for modulating chronic pain circuits, supported by evidence from both mouse and human studies.
Option 1: 'Occipital cortex stimulation improves color vision and pain perception' The occipital cortex is primarily involved in visual processing. There is no strong, consistent evidence that stimulating the occipital cortex reliably improves pain perception in chronic pain conditions, making this choice implausible as the most promising target for pain modulation.
Option 2: 'Posterior parietal cortex stimulation guarantees leads to recovery of sensory maps' The posterior parietal cortex is linked to multisensory integration and spatial attention, but the claim that stimulation guarantees recovery of sensory maps is overstated and not supported by robust evidence across chronic pain modulation studies in both mice and humans; the wording also overstates the therapeutic guarantee.
Option 3: 'Anterior cingulate cortex stimulation reduces both pain and affective distress' This option aligns with converging evidence from animal models and human studies that the anterior cingulate cortex (ACC) plays a key role in the affective dimension of pain, and targeted stimulation or neuromodulation of the ACC has been associated with reductions in pain unpleasantness and emotional distress, suggesting it as a promising cortical target for chronic pain modulation.
Option 4: 'Primary auditory cortex stimulation eliminates neuropathic pain' The primary auditory cortex is specialized for processing sound, not for pain modulation. There is no credible evidence that stimulating this region eliminates neuropathic pain, making this choice inconsistent with current understanding of pain networks and neurobiological targets found in mice and humans.
Overall, the reasoning favors ACC stimulation as the most evidence-backed cortical target for addressing both the sensory and affective aspects of chronic pain, whereas the other regions do not have the same level of supporting data or theoretical rationale for chronic pain modulation across species.

01:146:447:01 CLINICAL NEUROBIO CN F25 Exam 4

You are designing a clinical trial to modulate chronic pain circuits. Which cortical target is most promising based on evidence from both mouse and human studies?

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