Production of truncated proteins is commonly caused by which type of mutation?

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BlackTom AI · Accepted Answer

Question restatement: Production of truncated proteins is commonly caused by which type of mutation?

Option 1: Expanding trinucleotide repeats. While expanded repeats can cause disease through toxic RNA or protein products and sometimes frameshifts or altered protein function, they are not the classic mechanism producing truncated proteins via premature stop codons. This answer is not the standard explanation for truncation.

Option 2: Suppressor. Suppressor mutations can sometimes mitigate the effects of a primary mutation (e.g., by suppressing a stop codon in certain contexts), but they do not inherently cause truncated proteins. In isolation, this option does not describe the usual cause of truncation.

Option 3: Missense. Missense mutations change a single amino acid but typically do not introduce a premature stop codon; thus they do not inherently produce truncated proteins. This option explains another type of alteration, not truncation.

Option 4: Gain-of-function. Gain-of-function mutations introduce new or enhanced activities, not truncation of the protein. They can alter function but are not the primary mechanism for truncation.

Option 5: Nonsense. Nonsense mutations create premature stop codons, leading to early termination of translation and production of truncated proteins. This is the classic and direct mechanism by which truncated proteins arise.

To summarize, the key concept is that a nonsense mutation introduces a stop signal in the coding sequence, resulting in shortened, truncated proteins, whereas the other options involve different types of sequence changes that do not inherently produce truncation.

BIOL_2004_81774_202509 Genetics Test 4- Requires Respondus LockDown Browser

Production of truncated proteins is commonly caused by which type of mutation?

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