Which of the following is NOT a goal of docking/scoring?

Question

BlackTom AI · Accepted Answer

When considering the goals of docking and scoring procedures in structure-based drug design, several statements align with common objectives while one does not.
Option 1: 'Estimating the binding affinity of a ligand.' This is a core aim of docking/scoring, as the scoring function or docking score is intended to correlate with how strongly a ligand binds to the target receptor.
Option 2: 'Predicting ADMET properties.' ADMET (absorption, distribution, metabolism, excretion, and toxicity) predictions are typically handled by separate computational models or assays and are not a direct output of docking or scoring processes, making this statement inconsistent with docking goals.
Option 3: 'Determining the correct binding pose of the ligand in the receptor pocket.' A principal function of docking is to predict the plausible orientation and conformation of a ligand within the binding site, i.e., the binding pose.
Option 4: 'Separating out true ligands from molecules that don't actually bind.' This describes virtual screening or enrichment purposes, where the goal is to distinguish binders from non-binders, which is indeed a typical objective related to docking workflows.
Taken together, the statement about ADMET properties stands out as not belonging to the primary goals of docking/scoring, whereas the others reflect standard docking or related screening aims.

2254 BIOSC 1544 SEC1000 Exam #3- Requires Respondus LockDown Browser

Which of the following is NOT a goal of docking/scoring?

查看解析

登录即可查看完整答案

类似问题

Which type of docking scoring function predicts ligand binding using fundamental equations that calculate the energy of the protein/ligand interaction?

Which of the following best describes relaxed-complex (multiple-receptor) docking?

When using docking algorithm programs, you need to calculate the following interactions:

Match the Following Molecular flexibility techniques to the proper description. 1: Rigid Docking 2: Semi-Flexible Docking 3: Soft Docking 4:

What is one key difference between scoring functions and simulation-based methods for predicting binding energies?

What is the primary purpose of molecular docking in structure-based drug discovery?

What is the main advantage of the relaxed complex scheme in structure-based drug discovery?

In a consumer society, many adults channel creativity into buying things

更多留学生实用工具

考试浏览器助手

风格化写作助手

论文查重助手

文献引用助手

课堂转译助手

课堂笔记助手

Quiz搜索助手

学校历年真题

智能刷题助手

智能匹配练习

希望你的学习变得更简单