Mature skeletal muscle cannot undergo mitosis.

Question

BlackTom AI · Accepted Answer

The statement presented is about whether mature skeletal muscle can undergo mitosis. 
A common understanding is that mature skeletal muscle fibers are post-mitotic, meaning they have exited the cell cycle and do not divide by mitosis under normal adult conditions. This is due to their differentiation state: mature myofibers are large, multinucleated cells formed by fusion of precursor myoblasts, and their architecture is not conducive to typical cell division. 
However, it is important to distinguish the muscle tissue as a whole from its resident stem/progenitor cells. In the adult muscle, satellite cells (muscle stem cells) remain capable of proliferating and differentiating to repair or replace damaged fibers. This regenerative capacity occurs without the mature fibers themselves undergoing mitosis; instead, satellite cells re-enter the cell cycle, divide, and then fuse to form new or repaired muscle fibers. 
If one were to consider pathological or experimental contexts, there can be rare or specialized circumstances where virtually all cells in some tissues show unusual proliferative behavior, but in standard physiology, mature skeletal muscle fibers do not divide by mitosis. Thus the assertion aligns with the typical understanding of mature skeletal muscle being post-mitotic, with regeneration relying on satellite cell activity rather than division of mature fibers themselves.

BIOL-2401-099

Mature skeletal muscle cannot undergo mitosis.

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