Which one of the following best indicates what a nucleoside diphosphate kinase does?
Hint: Since it is a kinase, it is adding a phosphate; the name further indicates that a nucleoside diphosphate is the substrate for this kinase.

Question

BlackTom AI · Accepted Answer

The question asks what a nucleoside diphosphate kinase does, prompting us to recall its role in transferring phosphate groups and the substrate involved.
First, consider the hint: as a kinase, it adds a phosphate group. The substrate, as indicated by the name, is a nucleoside diphosphate (NDP). This frames the expected reaction mechanism: phosphoryl transfer to an NDP to form a nucleoside triphosphate (NTP).
Option assessment: 'adds a phosphate to the terminal phosphate of an NDP.' This description correctly captures the core action: the enzyme transfers a phosphate group to the diphosphate (the terminal phosphate) to generate an NTP. This aligns with the typical mechanism of nucleoside diphosphate kinases, which catalyze the exchange or transfer of phosphate between NDPs and ATP or from ATP to NDP, effectively converting NDP to NTP by adding a phosphate.
If there were alternative choices, we would evaluate them for potential misconceptions, such as suggesting the enzyme removes phosphate groups, acts on nucleoside triphosphates instead of diphosphates, or targets other substrates like proteins or sugars. However, given the provided option focuses on adding a phosphate to the NDP and the hint reinforces that interpretation, that option remains consistent with the known function of NDK.
In summary, the described action—increasing the phosphorylation state of an NDP by adding a phosphate to its terminal phosphate—is consistent with nucleoside diphosphate kinase activity and with its role in maintaining cellular NTP/NDP balance.

BIOL3611.13541.202610 InClassQuizChapter 15

Which one of the following best indicates what a nucleoside diphosphate kinase does? Hint: Since it is a kinase, it is adding a phosphate; the name further indicates that a nucleoside diphosphate is the substrate for this kinase.

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