For intramembranous ossification to take place, which of the following is necessary?

Question

BlackTom AI · Accepted Answer

To approach the question, I will evaluate what intramembranous ossification entails and compare each option against that process.
Option A: 'a bone collar forms around the cartilage model.' This describes endochondral ossification, not intramembranous ossification. The bone collar forms around a preexisting cartilage model in long bones, which is characteristic of endochondral development rather than the direct formation within a fibrous membrane.
Option B: 'a medullary cavity forms.' The formation of a medullary (marrow) cavity is typically associated with endochondral ossification as the cartilage model is remodeled to create a hollow cavity. Intramembranous ossification does not proceed through a cartilage template or create a medullary cavity in the same way.
Option C: 'ossification centers form in the fibrous connective tissue membrane.' This is the hallmark of intramembranous ossification: mesenchymal cells in a fibrous membrane differentiate directly into osteoblasts, forming ossification centers and laying down bone matrix without a cartilage intermediate.
Option D: 'the cartilage matrix begins to deteriorate.' This describes stepwise progression in endochondral ossification, where the cartilage model is gradually replaced by bone as chondrocytes die and the matrix is resorbed. It is not a feature of intramembranous ossification.
Thus, after weighing the options, the statement that aligns with intramembranous ossification is that ossification centers form in the fibrous connective tissue membrane, since this process proceeds directly from mesenchyme to bone without a cartilage stage.

For intramembranous ossification to take place, which of the following is necessary?

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