Vascular mimicry refers to when the cancer/antigen resembles the body’s own proteins/molecular marks to avoid immune attacks.

Question

Vascular mimicry refers to when the cancer/antigen resembles the body’s own proteins/molecular marks to avoid immune attacks.

BlackTom AI · Accepted Answer

The question asks about the concept of vascular mimicry and presents two statements to evaluate.
Option a) True: This would claim that vascular mimicry is the idea that cancer or antigens resemble the body's own proteins or molecular marks to avoid immune attacks. In reality, vascular mimicry does not refer to antigen or protein mimicry as an immune-escape strategy. Instead, it describes tumor cells forming vessel-like networks that resemble blood vessels, providing a perfusion pathway for tumors independent of normal angiogenesis. Therefore, interpreting vascular mimicry as immune disguise is a misconception.
Option b) False: This statement correctly identifies that vascular mimicry is not about mimicking the body's own proteins to dodge the immune system. The hallmark of vascular mimicry is tumor cells organizing into vasculature-like channels, enabling blood flow and nutrient delivery to the tumor without relying on endothelial cells. This mechanism is vascular mimicry, not antigenic mimicry.
A helpful way to separate the concepts is to recall that immune evasion via molecular mimicry would involve changes in antigen presentation or molecular camouflage, whereas vascular mimicry is structural functional mimicry of vasculature at the tissue level. Hence, the claim in option a) misstates the phenomenon, and option b) correctly states the misunderstanding as false.

Vascular mimicry refers to when the cancer/antigen resembles the body’s own proteins/molecular marks to avoid immune attacks.

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