A researcher observes that after prolonged exposure to a chemical, some individuals will in the future develop a disease condition due to that exposure. Which of Hill's criteria does this idea address?

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In this scenario, a researcher notes that prolonged exposure to a chemical is followed by the development of a disease in some individuals in the future.

Option 1 (Analogy): This criterion refers to using similarities between different diseases or exposure-disease relationships to infer causality. The described observation is about a temporal sequence in a specific exposure-disease pair, not about drawing an analogy to another situation, so this is not the best fit here.

Option 2 (Temporality): This is the key criterion at issue. Hill emphasized that the cause must precede the effect in time. Since the disease develops after prolonged exposure, the temporal sequence supports a potential causal relationship, satisfying temporality.

Option 3 (Consistency): Consistency concerns whether the association is repeatedly observed by different investigators, in different populations, and under different circumstances. The scenario describes a single observational idea about temporal order, not replication across studies, so consistency is not what is being addressed.

Option 4 (Strength of association): This criterion relates to how large the observed association is (e.g., risk or relative risk). The description mentions a causal sequence but does not comment on the magnitude of the association, so strength of association is not the focal criterion here.

PUBHEPI 2410 AU2025 (1751) Quiz Module 2: Practical applications of epidemiology

A researcher observes that after prolonged exposure to a chemical, some individuals will in the future develop a disease condition due to that exposure. Which of Hill's criteria does this idea address?

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