题目
题目

2254 BIOSC 1544 SEC1000 Exam #2

数值题

The drug aceclofenac has a carboxylate group with a pKa value of 3.4. Rounded to the nearest integer, what is the ratio of [deprotonated]/[protonated] aceclofenac, at physiological pH? Be sure to use the value for physiological pH that we discussed in class.

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思路分析
To determine the ratio of deprotonated to protonated aceclofenac at physiological pH, we apply the Henderson–Hasselbalch equation: pH = pKa + log([A-]/[HA]). Here, pKa = 3.4 and the physiological pH d......Login to view full explanation

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