Transport through the nuclear pore complex is regulated by the molecular switch, Ran. What drives the conformational change in Ran to drive transport across the nuclear membrane?

Question

BlackTom AI · Accepted Answer

The question asks what drives the conformational change in Ran that facilitates transport across the nuclear membrane.
First, we consider the Ran GTPase cycle: Ran cycles between ON (GTP-bound) and OFF (GDP-bound) states, and these nucleotide-bound states determine Ran’s conformation and interaction partners.
The key event that induces a conformational switch is the hydrolysis of GTP to GDP on Ran. When Ran-GTP is hydrolyzed to Ran-GDP, Ran adopts a different conformation that alters its binding affinities to transport receptors and cargo, driving the directionality of transport through the nuclear pore complex.
A corollary to this is that GTP hydrolysis is spatially regulated: RCC1 in the nucleus maintains Ran in the GTP-bound form, while RanGAP in the cytoplasm stimulates GTP hydrolysis to GDP, thus ensuring cargo release or receptor recycling as transport proceeds.
If one considers alternative statements often seen as distractors, options asserting that merely binding GTP (without hydrolysis) or GDP exchange alone (without hydrolysis) drives the step would be misleading. The conformational change that enables transport is specifically tied to the hydrolysis reaction converting GTP to GDP on Ran, not just nucleotide binding or exchange.
Additionally, since the data shows an empty list for answer options in this prompt, there is no further item to evaluate against, so the analysis centers on the canonical mechanism described above and why hydrolysis is the pivotal event in driving Ran’s conformational change during nuclear transport.

BIOT5750.39480.202530 Module 9 Quiz S25

Transport through the nuclear pore complex is regulated by the molecular switch, Ran. What drives the conformational change in Ran to drive transport across the nuclear membrane?

查看解析

登录即可查看完整答案

类似问题

In a consumer society, many adults channel creativity into buying things

Economic stress and unpredictable times have resulted in a booming industry for self-help products

People born without creativity never can develop it

A product has a selling price of $20, a contribution margin ratio of 40% and fixed cost of $120,000. To make a profit of $30,000. The number of units that must be sold is: Type the number without $ and a comma. Eg: 20000

Which of the following statement regarding cost is correct:

Under the assumptions used in cost-volume-profit analysis, as the activity increases:

The CVP and break-even analysis are supported by a range of important assumptions. Which of the following is not an assumption of the CVP:

The break-even point is that at which:

更多留学生实用工具

考试浏览器助手

风格化写作助手

论文查重助手

文献引用助手

课堂转译助手

课堂笔记助手

Quiz搜索助手

学校历年真题

智能刷题助手

智能匹配练习

希望你的学习变得更简单