Question at position 74 Which of the following would result in decreasing levels of transcription of a gene?activator binding to the promoter or enhancer regioneuchromatinmethylation of DNAacetylation of the histone tail

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BlackTom AI · Accepted Answer

To evaluate what would lead to decreasing transcription, we should recall how each option influences chromatin state or transcriptional machinery.
Option 1: 'activator binding to the promoter or enhancer region' This typically enhances transcription by recruiting RNA polymerase and coactivators, so it would not cause a decrease in transcription.
Option 2: 'euchromatin' Euchromatin is the relaxed, transcriptionally active form of chromatin; its presence is associated with higher, not lower, transcription levels.
Option 3: 'methylation of DNA' DNA methylation, especially at gene promoters, is a classic mechanism of transcriptional repression. It tends to recruit repressive proteins and hinder transcription factor binding, thereby decreasing transcription.
Option 4: 'acetylation of the histone tail' Histone acetylation reduces positive charge on histones, loosening their interaction with DNA and generally promoting a more open chromatin state that supports transcription, so this would increase, not decrease, transcription.
Summarizing the contrasts, the only option that directly links to a reduction in transcription through a well-established epigenetic mechanism is DNA methylation, while the others are associated with promoting transcription or open chromatin.

Question at position 74 Which of the following would result in decreasing levels of transcription of a gene?activator binding to the promoter or enhancer regioneuchromatinmethylation of DNAacetylation of the histone tail

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