Question at position 49 Select any way in which we could make someone with lactose intolerance get lactose tolerance?Edit the noncoding DNA regulating lactase gene to turn lactase gene offGive them lactase enzyme manufactured from another biological source.Edit the noncoding DNA regulating lactase gene to turn lactase gene on

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BlackTom AI · Accepted Answer

When considering how to enable lactose tolerance, we must evaluate what each option would do to lactase activity and lactose digestion.
Option 1: Edit the noncoding DNA regulating the lactase gene to turn lactase gene off. Turning the gene off would reduce or eliminate lactase production, which would worsen lactose intolerance rather than alleviate it. This would remove the body's ability to digest lactose, so it is not a viable approach to achieve lactose tolerance.
Option 2: Give them lactase enzyme manufactured from another biological source. Providing external lactase enzymes can supplement the body's own enzyme, enabling digestion of lactose in dairy products even in individuals who are lactose intolerant. This is a practical, currently used strategy to reduce symptoms, and it does not require genetic changes.
Option 3: Edit the noncoding DNA regulating lactase gene to turn lactase gene on. Many cases of lactose tolerance (lactase persistence) are associated with continued expression of lactase into adulthood. If noncoding regulatory DNA were edited to enhance or maintain lactase expression, the result could be ongoing lactase production, thereby increasing lactose tolerance. Conceptually, this aligns with turning the gene on and sustaining its activity, making it a theoretical but plausible approach to achieve tolerance.
In summary, option 1 would worsen the condition, option 2 offers a direct, existing means to tolerate lactose, and option 3 represents a genetic strategy aimed at maintaining or increasing lactase production to achieve tolerance.

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