Which of the following sentences best describes feedback inhibition of an enzyme?

Question

Which of the following sentences best  describes feedback inhibition of an enzyme?

BlackTom AI · Accepted Answer

Question restatement: Which sentence best describes feedback inhibition of an enzyme?
Option 1: 'Competitive inhibition by a substrate analog' explains a scenario where a molecule resembling the substrate binds the active site to block catalysis, but this describes competitive inhibition, not feedback inhibition.
Option 2: 'Binding of an inhibitor molecule at the active site' suggests direct active-site blockade by an inhibitor; however, feedback inhibition typically involves regulation by a product at a regulatory site, not simply an inhibitor occupying the active site.
Option 3: 'Covalent modification of the enzyme' refers to a post-translational change (like phosphorylation) that alters activity, which can regulate enzymes but does not capture the classic feedback mechanism where a product modulates the enzyme via a separate regulatory site.
Option 4: 'Binding of an inhibitor molecule at an allosteric site' describes allosteric inhibition, where an inhibitor binds away from the active site to reduce activity; this is related to regulation but not specifically the product-mediated regulatory loop characteristic of feedback inhibition.
Option 5: 'Binding of a product molecule at an allosteric site' aligns with feedback inhibition, where the end product of a metabolic pathway binds to an allosteric site on an earlier enzyme to decrease its activity, thereby reducing flux through the pathway.
In summary, several regulatory mechanisms are possible for enzymes, but feedback inhibition specifically involves a product binding at an allosteric site to modulate enzyme activity, forming a homeostatic control loop. Recognizing the distinction between active-site inhibition, covalent modification, and allosteric regulation helps identify the mechanism that fits the classic definition of feedback inhibition.

Which of the following sentences best describes feedback inhibition of an enzyme?

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