Question4 Some enzymes show feedback inhibition where products formed are their own inhibitors. In the biochemical pathway shown below, which enzyme is the best one to be inhibited by product A from the pathway, so it is shut down in the most energy efficient manner? Input your answer as a single whole number representing the enzyme number that you choose (i.e. input either 1, 2, 3 or 4). Answer: [input] .
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BlackTom AI · Accepted Answer

When considering feedback inhibition by product A, the most energy-efficient control point is usually at or before the first committed step of the pathway. 
Option 1 (Enzyme 1): Inhibiting Enzyme 1 would prevent the formation of all downstream intermediates and the final product, stopping flux early and avoiding wasted ATP or precursor usage for later steps. This is the classic strategy to conserve energy and resources by halting the pathway at its source. 
Option 2 (Enzyme 2): If Enzyme 2 were inhibited rather than Enzyme 1, the pathway would still funnel substrate A into the initial intermediate, wasting energy on producing intermediates that cannot be converted to product without Enzyme 2 activity. The inhibition point is downstream and less energy-efficient. 
Option 3 (Enzyme 3): Inhibiting Enzyme 3 still allows the initial steps to proceed, generating intermediates that cannot reach the final product due to downstream blockage. This approach wastes more ATP and reducing equivalents than stopping earlier. 
Option 4 (Enzyme 4): Blocking the final enzymatic step prevents product formation but leaves earlier steps operating, potentially accumulating intermediates and consuming resources without yielding product. This is energetically less efficient than cutting flux earlier at Enzyme 1. 
Overall, the most energy-efficient shutoff is to inhibit the first enzyme in the sequence, Enzyme 1, because it blocks the pathway before energy-containing steps are spent on producing intermediates that would be unused.

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