Tolerance refers to needing less of a substance over time to achieve the same effect.

Question

BlackTom AI · Accepted Answer

This true/false statement asks about the concept of tolerance in substance use. 
Option 1: True. The claim that tolerance means needing less of a substance over time to achieve the same effect is inaccurate. In pharmacology and substance use, tolerance typically develops when more of the substance is required to achieve the same level of effect, reflecting decreased sensitivity to the drug over time. Saying it’s the other way around would describe sensitization rather than tolerance, which is not the common pattern for most substances with repeated use.
Option 2: False. The claim describes a phenomenon opposite to the standard definition of tolerance. Tolerance is the process by which the body adapts to a drug, leading to diminished response to a given dose, which usually leads people to increase the dose to regain the prior effect. The statement as written mischaracterizes this relationship, conflating it with the inverse concept.
The first option presents a common misconception by reversing the direction of the tolerance process, while the second option correctly identifies that tolerance does not involve needing less but often more of a substance to achieve the same effect.

2025SP-HES-145-002 Quiz 10 - Addiction/Drugs/Alcohol

Tolerance refers to needing less of a substance over time to achieve the same effect.

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