Prolonged exposure to an agonist leading to a diminished response despite continued presence of the drug is known as:

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Question restatement: Prolonged exposure to an agonist leading to a diminished response despite continued presence of the drug is known as:

Option 1 - Bioavailability: Bioavailability refers to the fraction of an administered dose that reaches systemic circulation and is available to have an effect. It is about the amount of drug that enters the bloodstream, not about the body’s changing response over time with continued exposure. This option does not describe a decreased response due to ongoing drug presence.

Option 2 - Tolerance: Tolerance describes a pharmacodynamic or pharmacokinetic phenomenon where a person’s response to a drug diminishes with repeated use, requiring higher doses to achieve the same effect, even though the drug is still present. This directly matches the scenario of diminishing response despite continued exposure.

Option 3 - Potentiation: Potentiation occurs when one drug increases the effect of another drug, enhancing potency beyond what would be expected from either drug alone. This is about interaction that elevates effects, not a reduced response due to continued exposure.

Option 4 - Synergism: Synergism refers to two or more drugs producing an effect greater than the sum of their individual effects. Like potentiation, this describes an enhanced combined action, not a decreased response from prolonged exposure to a single drug.

In summary, among the choices, the phenomenon that best fits the description of a diminished response after ongoing exposure to the agonist is tolerance, while the other terms describe different pharmacokinetic or pharmacodynamic relationships.

PCOL2021 (ND) Module 1 Quiz

Prolonged exposure to an agonist leading to a diminished response despite continued presence of the drug is known as:

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