Diretinil and triretinil are structurally similar drugs and follow similar pathways of liver metabolism and renal elimination. However, diretinil is highly bound to serum albumin while triretinil does not bind extensively to serum albumin. Predict which ONE of the following options is likely to be CORRECT?

Question

Diretinil and triretinil are structurally similar drugs and follow similar pathways of liver metabolism and renal elimination. However, diretinil is highly bound to serum albumin while triretinil does not bind extensively to serum albumin. Predict which ONE of the following options is likely to be CORRECT?

BlackTom AI · Accepted Answer

The question presents two structurally similar drugs, Diretine1l (diretinil) and Triretinil, with the key difference that diretinil is highly bound to serum albumin while triretinil has little albumin binding, and asks which statement is likely correct regarding their elimination.
Option 1: 'The rate of elimination are unrelated to binding to serum albumin.' In pharmacokinetics, protein binding generally influences the free (unbound) drug concentration, which is the portion available for filtration and metabolism. While binding is not the sole determinant of elimination, it is a major factor because only the unbound drug is usually cleared efficiently. Therefore claiming no relationship between binding and elimination tends to overlook a fundamental principle, making this option questionable.
Option 2: 'Serum binding prevents the elimination of drugs.' This is an overstatement. Binding to serum albumin does not completely prevent elimination; it slows it by reducing the unbound fraction, but the drug can still be cleared over time via metabolism and excretion. Saying it prevents elimination ignores the mechanism by which bound drug can dissociate and be eliminated.
Option 3: 'The rate of elimination of triretinil is likely to be slower than that of diretinil.' Given that triretinil binds less to albumin, a larger unbound fraction would typically be available for renal filtration and metabolic clearance, which would drive faster elimination relative to Diretine1l. Thus this statement contradicts the expected effect of high albumin binding on elimination rate for diretinil.
Option 4: 'The rate of elimination of diretinil is likely to be slower than that of triretinil.' This aligns with the pharmacokinetic principle that high protein binding reduces the free concentration of drug available for clearance, leading to a slower elimination rate for the highly bound diretinil compared to the less bound triretinil. The unbound drug is the portion that undergoes metabolism and renal excretion, so with diretinil’s high binding, its clearance tends to be reduced, prolonging its time in the body.
In summary, the core concept here is that serum albumin binding reduces the unbound drug fraction, which often correlates with a slower elimination rate, while a drug with little albumin binding is more readily cleared. Options that deny a link between binding and elimination or that reverse the expected relationship fail to reflect this principle, whereas the statement consistent with high binding slowing elimination captures the typical pharmacokinetic behavior of highly bound compounds.

PCOL2021 2025 Module 3 Quiz

查看解析

登录即可查看完整答案

类似问题

In a consumer society, many adults channel creativity into buying things

Economic stress and unpredictable times have resulted in a booming industry for self-help products

People born without creativity never can develop it

A product has a selling price of $20, a contribution margin ratio of 40% and fixed cost of $120,000. To make a profit of $30,000. The number of units that must be sold is: Type the number without $ and a comma. Eg: 20000

Which of the following statement regarding cost is correct:

Under the assumptions used in cost-volume-profit analysis, as the activity increases:

The CVP and break-even analysis are supported by a range of important assumptions. Which of the following is not an assumption of the CVP:

The break-even point is that at which:

更多留学生实用工具

考试浏览器助手

风格化写作助手

论文查重助手

文献引用助手

课堂转译助手

课堂笔记助手

Quiz搜索助手

学校历年真题

智能刷题助手

智能匹配练习

希望你的学习变得更简单