Cyclophosphamide must be activated by which organ before it can cause crosslinks between DNA strands?

Question

Cyclophosphamide must be activated by which organ before it can cause crosslinks between DNA strands?

BlackTom AI · Accepted Answer

The question asks which organ activates cyclophosphamide before it can cause crosslinks between DNA strands.
Option a) Heart: The heart is not the primary site of cyclophosphamide activation; it doesn’t perform the metabolic conversion to the active cytotoxic species.
Option b) Kidney: Although some drugs are excreted or activated in the kidney, activation of cyclophosphamide is not mainly occurring there.
Option c) Liver: Correct. Cyclophosphamide is a prodrug that requires activation by hepatic cytochrome P450 enzymes. In the liver, it is oxidized to 4-hydroxycyclophosphamide, which equilibrates to aldophosphamide and ultimately yields phosphoramide mustard, the species responsible for crosslinking DNA strands and exerting cytotoxic effects.
Option d) Brain: The brain is not the site of cyclophosphamide activation; it does not perform the metabolic oxidation steps required for activation.
Option e) Spleen: While the spleen has metabolic activity, the established primary organ for activating cyclophosphamide is the liver, not the spleen.
In summary, activation occurs in the liver via hepatic cytochrome P450 enzymes, enabling the formation of DNA crosslinking agents, whereas the other listed organs are not the sites of this critical metabolic activation.

Cyclophosphamide must be activated by which organ before it can cause crosslinks between DNA strands?

查看解析

登录即可查看完整答案

类似问题

Which of the following statements about metabolism is TRUE:[Fill in the blank]

How does the enzyme CYP3A4 contribute to drug metabolism?[Fill in the blank]

Which of the following statements about metabolism is TRUE:

If a prodrug is converted into its bioactive form through metabolism by a cytochrome P450 enzyme then:

Which is primarily responsible for pharmacologic metabolism?

The liver has an important role in drug ADME. Which ONE of the following is CORRECT?

Where are lidocaine, mepivacaine, and bupivacaine metabolized?

更多留学生实用工具

考试浏览器助手

风格化写作助手

论文查重助手

文献引用助手

课堂转译助手

课堂笔记助手

Quiz搜索助手

学校历年真题

智能刷题助手

智能匹配练习

希望你的学习变得更简单