Which one of the following statements about modern day drug discovery is INCORRECT?

Question

BlackTom AI · Accepted Answer

When evaluating the statements about modern day drug discovery, it helps to test each claim against current practice and limitations.
Option A: 'Knowledge of the protein structure of drug targets has enabled compound screening to be conducted in silico.' This is largely true. Structure-based drug design and computational docking enable in silico screening, allowing researchers to prioritize compounds before any physical testing.
Option B: 'Liquid handling technologies have enhanced the cost-effectiveness of high throughput compound screening.' This is accurate. Automated liquid handling improves precision and throughput, reducing per-assay costs and enabling large-scale screens.
Option C: 'Assays used in high throughput compound screening are so effective that they can identify drugs that immediately go into clinical trials.' This is misleading. While HTS can identify hit compounds, many hits require extensive validation, optimization, toxicity assessment, and pharmacokinetic studies before clinical trials are considered. A high hit rate in HTS does not guarantee immediate progression to clinical trials; false positives, poor drug-like properties, and safety concerns are common hurdles.
Option D: 'Artificial intelligence has been used to discover novel antibiotics.' This statement is consistent with current trends. AI/ML has been applied to antibiotic discovery, including identifying novel compounds or repurposing strategies, and is an active area of research.
Thus, Option C is the incorrect statement, while A, B, and D reflect established or emerging practices in modern drug discovery.

PHRM20001_2025_SM2 Exam: Pharmacology: How Drugs Work (PHRM20001_2025_SM2)- Requires Respondus LockDown Browser

Which one of the following statements about modern day drug discovery is INCORRECT?

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