Calculate the frequency of the following DNA profile.

TPOX (6,12) vWA (15,21) THO1 (9,9.3).

Example: 10^-4 is equal to 10-4

Question

Calculate the frequency of the following DNA profile.

TPOX (6,12) vWA (15,21) THO1 (9,9.3).

Example: 10^-4 is equal to 10-4

BlackTom AI · Accepted Answer

The question asks to calculate the frequency of a DNA profile: TPOX (6,12) vWA (15,21) THO1 (9,9.3). Example: 10^-4 is equal to 10-4.

First, note what information is needed to compute the overall profile frequency: for each locus (TPOX, vWA, THO1), you need the allele frequencies of the observed alleles (6 and 12 for TPOX; 15 and 21 for vWA; 9 and 9.3 for THO1) in the relevant population.

Next, understand the standard approach: if the two alleles at a locus are different (a heterozygous genotype), you typically multiply the frequencies of those two alleles together for that locus. If the two alleles are the same (homozygous), you multiply the single allele frequency by (2 minus the observed duplicates) or more simply use the square of the allele frequency depending on the exact convention used (often f(allele)^2 for homozygous). Then you multiply the locus frequencies across all loci to obtain the overall profile frequency: F = f(TPOX 6) × f(TPOX 12) × f(vWA 15) × f(vWA 21) × f(THO1 9) × f(THO1 9.3).

Important caveat: to perform these calculations you must have the population allele frequencies for each allele at each locus. Without those frequencies, you cannot compute a numerical result.

In this specific prompt, the answer field provides a numeric result (7.37 * 10^-10), but the necessary allele frequency data and the answer options are not provided. Without the allele frequency tables or a given set of candidate options to compare, we cannot verify or reproduce that numeric value.

If you were given allele frequencies, here is how you would proceed in a concrete step-by-step way:
- Step 1: Retrieve f(TPOX 6) and f(TPOX 12) from the relevant population database. If the two alleles are different, compute F_TPOX = f(6) × f(12). If they were the same, compute F_TPOX = f(6)² (and apply the correct sampling convention if specified in your course materials).
- Step 2: Retrieve f(vWA 15) and f(vWA 21). If different, F_vWA = f(15) × f(21).
- Step 3: Retrieve f(THO1 9) and f(THO1 9.3). If different, F_THO1 = f(9) × f(9.3).
- Step 4: Multiply the locus frequencies: F = F_TPOX × F_vWA × F_THO1.
- Step 5: Express the final result in scientific notation (e.g., a × 10^b) as required by your formatting convention.

Given the missing options and allele frequency data in the prompt, the numerical value 7.37 × 10^-10 cannot be independently verified here. If you supply the allele frequency table or the list of answer options, I can walk through the exact calculation and show which choice matches the computation.

ETX 020 001 WQ 2025 Assignment 3: DNA Profile Frequency

Calculate the frequency of the following DNA profile. TPOX (6,12) vWA (15,21) THO1 (9,9.3). Example: 10^-4 is equal to 10-4

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