A single stranded DNA molecule can

Question

BlackTom AI · Accepted Answer

Consider the possibilities for a single-stranded DNA (ssDNA) molecule and how it can interact with other nucleic acids.
Option 1 suggests ssDNA can only interact by homology with its complement. In reality, ssDNA can engage in non-complementary or partial-homology interactions, especially if there are complementary-like regions within itself or with other strands, so this statement is too restrictive.
Option 2 claims interactions occur only with itself and fold by homologous sequences. While self-complementarity can cause folding, ssDNA interactions are not limited to perfect homologous folding; partial or imperfect matches can still occur with other sequences, making this option incomplete.
Option 3 states that ssDNA can have partial homologous interactions with itself or a second DNA/RNA molecule if the sequence allows. This captures the nuance that partial regions of homology can drive interactions both intramolecularly (self) and intermolecularly (with another strand), and it acknowledges that such interactions depend on sequence features.
Option 4 asserts interactions only with a second DNA molecule, which ignores the possibility of self-interaction and internal folding driven by intra-strand complementarity, as well as potential interactions with RNA or other nucleic acids. This is overly restrictive and inaccurate for the broad behavior of ssDNA.
In summary, the most accurate description is that ssDNA can engage in partial homologous interactions with itself or with a second DNA or RNA molecule depending on sequence compatibility, which aligns with known nucleic acid behavior and pairing dynamics.

A single stranded DNA molecule can

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