Which of the following did NOT play a role in the eradication of smallpox?

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Question: Which of the following did NOT play a role in the eradication of smallpox?

Option a: The availability of effective antiviral agents that block replication
- This did not play a role in eradication. There were no effective antiviral drugs for smallpox used in the eradication effort; antiviral therapies were not a part of the strategy, and smallpox was controlled primarily through vaccination and public health measures rather than pharmacological blockers of viral replication.

Option b: The World Health Organisation organised and led a global eradication plan
- This clearly did play a role. WHO coordinated the global smallpox eradication campaign, standardizing practices, surveillance, and containment strategies across countries, which was central to the effort.

Option c: No known reservoir outside of human hosts
- This also played a role. The fact that smallpox did not have an animal reservoir made eradication feasible because transmission occurred only between humans, allowing a finite end to transmission with vaccination and surveillance.

Option d: Ease of diagnosis by readily recognized clinical features
- This contributed to eradication. The distinctive rash and clinical presentation of smallpox facilitated rapid case identification, isolation, and ring vaccination strategies, aiding containment.

Option e: An effective vaccine was produced
- This was essential. The successful development and deployment of a safe and effective smallpox vaccine underpinned the eradication program, enabling population immunity and herd protection.

Summary: Among the options, only a states the existence of antiviral agents as a key factor, which is incorrect for smallpox eradication history. All the other factors listed (WHO-led global plan, human-only reservoir, recognizable clinical features aiding diagnosis, and effective vaccination) did play roles in eradication.

2025-PSB-MIC1IPE(SP-T3-FT) - INFECTIONS, PANDEMICS AND EPIDEMICS

Which of the following did NOT play a role in the eradication of smallpox?

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