Question16 E = enzyme, S = Substrate, I = Inhibitor Select the term which best describes the type of enzyme inhibition shown in the diagram above. Select one alternative: Allosteric Non-competitive Competitive Irreversible Lineweaver-Burke ResetMaximum marks: 1 Flag question undefined

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BlackTom AI · Accepted Answer

To approach this question, I will evaluate what each term means in enzyme inhibition and compare it to what is depicted in the diagram.

Option 1: Allosteric. Allosteric inhibitors bind to a site other than the active site (an allosteric site) and induce conformational changes that affect enzyme activity. If the diagram showed inhibitor binding at a separate site causing a change in E's shape and affecting both E and E–S formation, this could be allosteric. However, in the image, the inhibitor appears to interact with the enzyme at the same region involved in substrate binding, that is, near the active site area where substrate S binds. This makes allosteric inhibition unlikely here.

Option 2: Non-competitive. Non-competitive inhibition occurs when an inhibitor binds to a site distinct from the active site and inhibits enzyme activity regardless of substrate binding, often reducing Vmax without affecting Km. In the diagram, the inhibitor seems to block formation of the E–S complex by occupying the enzyme in a manner that prevents substrate binding, rather than simply decreasing catalytic efficiency after binding. Therefore, this does not match classic non-competitive behavior as depicted.

Option 3: Competitive. Competitive inhibition involves the inhibitor competing with the substrate for binding at the active site of the enzyme. The typical appearance is that the inhibitor and substrate vie for the same site, and the enzyme–inhibitor complex prevents substrate binding while allowing the enzyme–substrate complex when the inhibitor concentration is overcome by substrate. The diagram shows I approaching the same region where S would bind to E, leading to the formation of an E–I complex at the active site and preventing E from binding S. This aligns with competitive inhibition.

Option 4: Irreversible. Irreversible inhibition occurs when the inhibitor forms a permanent covalent or very strong bond with the enzyme, permanently inactivating it. The diagram does not suggest covalent modification or permanent inactivation; instead, it depicts reversible occupancy at the active site by I, which is characteristic of competitive inhibition, not irreversible inhibition.

Option 5: Lineweaver-Burke. This is not a type of inhibition; it is a linear transformation (Lineweaver–Burke plot) used to analyze enzyme kinetics and distinguish inhibition types. Since the question asks for the descriptor of the inhibition type, this option is not a direct description of the mechanism shown.

In summary, the visual evidence in the diagram corresponds to inhibitor occupying the active site and blocking substrate binding, which is the hallmark of competitive inhibition. Other options describe different mechanisms or analytical tools that do not fit the depicted interaction.

Question16 E = enzyme, S = Substrate, I = Inhibitor Select the term which best describes the type of enzyme inhibition shown in the diagram above. Select one alternative: Allosteric Non-competitive Competitive Irreversible Lineweaver-Burke ResetMaximum marks: 1 Flag question undefined

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