True or False: A single-arm trial includes multiple groups that are randomly assigned to different treatments.

Question

BlackTom AI · Accepted Answer

In this question, we are evaluating the structure of a single-arm trial versus randomized designs.
Option a) 'True' would assert that a single-arm trial includes multiple groups that are randomly assigned to different treatments. This is incorrect because a single-arm trial involves only one group of participants who all receive the same treatment, with no randomization to alternative groups or treatments.
Option b) 'False' correctly reflects the idea that a single-arm trial does not have multiple groups or random assignment to different treatments. By design, there is only one treatment condition and no comparator or randomization scheme to allocate participants to different arms.
To contrast with the statement, consider that a randomized controlled trial (RCT) typically features at least two groups (e.g., treatment vs. control) and uses random assignment to allocate participants to those groups. That setup is the opposite of a single-arm trial, which lacks these comparative groups and randomization.
In summary, the claim in option a) mischaracterizes what a single-arm trial is, while option b) accurately describes it as not having multiple randomly assigned groups.

True or False: A single-arm trial includes multiple groups that are randomly assigned to different treatments.

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