Which of the following is NOT an example of a receptor tyrosine kinase?[Fill in the blank]

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Question: Which of the following is NOT an example of a receptor tyrosine kinase?

Option a: A Fibroblast growth factor receptor
This is a classic receptor tyrosine kinase (RTK). FGFRs have an extracellular ligand-binding domain, a single transmembrane helix, and an intracellular tyrosine kinase domain that autophosphorylates upon ligand binding.

Option b: An Interleukin 1 receptor
This receptor does not possess intrinsic tyrosine kinase activity. IL-1 receptor signaling occurs via adaptor proteins like MyD88 and downstream kinases such as IRAK, leading to NF-κB activation. It is not classified as an RTK.

Option c: A vascular endothelial growth factor receptor
VEGFRs are well-known RTKs with extracellular ligand binding, a single transmembrane segment, and an cytoplasmic tyrosine kinase domain that becomes activated upon ligand binding.

Option d: An insulin receptor
The insulin receptor is a prototypical RTK. It auto-phosphorylates on tyrosine residues and propagates signaling through pathways like PI3K-AKT and MAPK.

Summary: Options a, c, and d are all receptor tyrosine kinases, each possessing an extracellular ligand-binding domain, a transmembrane region, and an intracellular tyrosine kinase domain, and they propagate signals via tyrosine phosphorylation. Option b lacks intrinsic tyrosine kinase activity and uses adaptor proteins for signal transduction, so it is not an RTK.

Which of the following is NOT an example of a receptor tyrosine kinase?[Fill in the blank]

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Which of the following is NOT an example of a receptor tyrosine kinase?[Fill in the blank]

查看解析

登录即可查看完整答案

类似问题

Question at position 44 A hormone is an example of which type of cell cycle signal?endogenousexogenous

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Which of the following will be affected by a compound that gets rid of ATP?

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Insulin is a Blank ______ hormone and thus triggers a cellular response by Blank ______.

Insulin binds to specific receptors on the plasma membranes of its target cells. This binding triggers pathways that influence transport proteins and intracellular enzymes of the target cell.

Question at position 48 Which signaling mechanism uses neurotransmitters to communicate between a neuron and a target cell at a short range?Autocrine signalingParacrine signalingSynaptic signalingEndocrine signaling

更多留学生实用工具

希望你的学习变得更简单

Insulin is a Blank hormone and thus triggers a cellular response by Blank .