Gap junctions permit intercellular movement of a variety of ions and small molecules.

Question

BlackTom AI · Accepted Answer

Consider the statement carefully: gap junctions are channels that directly connect the cytoplasm of adjacent cells, allowing certain substances to pass between them. 
Option 1: True. This is correct because gap junctions formed by connexin (in vertebrates) or innexin (in invertebrates) proteins create aqueous pores that permit the diffusion of ions (e.g., Na+, K+, Ca2+), second messengers (such as IP3 and cAMP), and small metabolites, enabling coordinated intercellular signaling and electrical coupling in tissues like heart and smooth muscle. The permeability is size- and charge-dependent, typically accommodating molecules up to roughly ~1 kDa, which includes many small signaling molecules. 
Option 2: Flase. This option is incorrect for two reasons: first, it contains a spelling error that signals a distractor; second, even if one overlooked the typo, the content of the option contradicts established biology since gap junctions do permit intercellular movement of ions and small molecules. If someone claimed they do not, they would be denying a fundamental property of gap junctions and misrepresenting the role of connexin/innexin channels. 
In summary, the true statement aligns with the known function of gap junctions in facilitating direct cytoplasmic exchange of ions and small molecules, while the alternative either misleads through misspelling or asserts a false claim about their permeability.

AVBS2005 (ND) Cytology II

Gap junctions permit intercellular movement of a variety of ions and small molecules.

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