Chromosome replication in a somatic cell takes place during

Question

BlackTom AI · Accepted Answer

The question asks about when chromosome replication in a somatic cell occurs, so we need to consider the stages of the cell cycle and what happens in each.
Option 1: metaphase. Metaphase is part of mitosis, when chromosomes align at the cell's equator before separation. No DNA replication happens here; replication occurs earlier in the cycle, so this choice is incorrect.
Option 2: anaphase. Anaphase is also a mitotic stage, where sister chromatids are pulled apart toward opposite poles. Since replication has already occurred before mitosis begins, this timing is not when replication happens, making this option incorrect.
Option 3: late prophase. Prophase is the early stage of mitosis when chromosomes condense and the nuclear envelope breaks down. While this is associated with chromosome preparation for segregation, replication itself does not occur here; replication must have preceded mitosis, so this is incorrect.
Option 4: interphase. Interphase encompasses G1, S, and G2 phases, with the S (synthesis) phase specifically dedicated to DNA replication. This is the correct context for replication of chromosomes in a somatic cell, as the cell duplicates its DNA before entering mitosis.
In summary, replication of chromosomal DNA in somatic (non-germline) cells is tightly linked to the S phase within interphase, whereas the subsequent mitotic stages (prophase, metaphase, anaphase) involve chromosome condensation, alignment, and segregation rather than replication.

BIOL 1009 (001-006/050-055) Midterm Exam II

Chromosome replication in a somatic cell takes place during

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