In the following pedigree, what is the likely mode of transmission of the indicated trait?

Question

BlackTom AI · Accepted Answer

To determine the mode of transmission, I will evaluate each option against the pattern observed in the pedigree.
Option 1: Y-linked. Y-linked traits are transmitted from affected fathers to all of their sons and never through females. In this pedigree, both males and females are affected across multiple generations, and affected females appear as well as affected males. This rules out a Y-linked pattern.
Option 2: autosomal dominant. In autosomal dominant inheritance, the trait appears in every generation and affects both sexes roughly equally. Affected individuals can have unaffected parents, but typically an affected person has at least one affected parent, and there is vertical transmission across generations. The diagram shows multiple affected individuals in successive generations (I to II to III to IV) with both males and females affected, which aligns with autosomal dominant expectations. This is a plausible fit for the shown data.
Option 3: X-linked dominant. X-linked dominant traits also affect both sexes and can appear in every generation, but they often show a higher proportion of affected females due to the presence of two X chromosomes in females and usually transmission from affected fathers to all daughters but no sons. The pedigree provided does not display a clear pattern of preferential transmission to daughters or a consistent father-to-daughter rule, making this option less consistent with the overall distribution.
Option 4: X-linked recessive. X-linked recessive traits typically affect mostly males and may skip generations, as females can be carriers without being affected. Since the pedigree shows a substantial number of affected females as well as males, and there is clear vertical transmission through generations without a predominance of affected males, this option is unlikely.
Option 5: autosomal recessive. Autosomal recessive traits often skip generations and may require both parents to be carriers, with affected individuals clustered among siblings rather than across every generation. The consistent appearance of affected individuals in successive generations and both sexes argues against a purely recessive pattern here.
Overall, the pattern of affected individuals across generations and in both sexes best matches autosomal dominant inheritance, rather than the other listed modes.

BIOL_2004_81774_202509 Homework 1

In the following pedigree, what is the likely mode of transmission of the indicated trait?

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