The process of autophagy depends on ATP

Question

BlackTom AI · Accepted Answer

Question restatement: The process of autophagy depends on ATP. True/False.

Option analysis:
- Since this is a true/false item with the statement given and no alternative choices provided, we evaluate the claim directly.

Understanding autophagy: Autophagy is an energy-dependent catabolic process in which cells degrade and recycle cytoplasmic components. ATP is required at multiple stages, including the formation of autophagosomes, their maturation, and fusion with lysosomes to form autolysosomes. Enzymatic activities and motor proteins that transport autophagic vesicles also rely on ATP.

Why the statement is true: The overall process consumes energy in order to assemble autophagosomes, rearrange membranes, and drive vesicle fusion and degradation. The involvement of ATP is well-established in autophagy regulation and execution, consistent with the cellular need to fuel membrane dynamics and proteolytic steps.

Why the statement is not misleading: While certain regulatory checkpoints can be influenced by energy status (e.g., AMPK activation under low energy), and autophagy can be upregulated when energy is scarce, the necessity of ATP for the core steps remains fundamental rather than optional.

In summary, the claim that autophagy depends on ATP aligns with the biochemical understanding of the autophagic pathway, which requires energy input for vesicle formation, transport, and lysosomal degradation.

2261 BIOSC 1500 SEC1030 Cell Bio 1500'25 first midterm, 75 min version

The process of autophagy depends on ATP

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