Lysosomes fuse with autophagosomes to form autolysosomes

Question

BlackTom AI · Accepted Answer

Consider the cellular process of autophagy and how material is degraded within the cell.
First, an autophagosome forms when a portion of cytoplasm or a damaged organelle is sequestered inside a double-membrane vesicle.
Next, this autophagosome must be delivered to and fuse with a lysosome for digestion to occur; the resulting hybrid is commonly referred to as an autolysosome or autophagolysosome.
Inside this autolysosome, lysosomal hydrolases become active and break down the enclosed material, allowing nutrients to be recycled by the cell.
If we were to consider the statement, it asserts that lysosomes fuse with autophagosomes to form autolysosomes, which aligns with the accepted understanding of the autophagy degradation pathway.
A potential misconception might involve confusing autolysosome formation with other fusion events, such as endosome-lysosome fusion in different trafficking contexts, but in the scope of autophagy, lysosome-autophagosome fusion is precisely what creates the autolysosome.
In sum, the sequence is autophagosome formation, fusion with a lysosome, and the formation of an autolysosome where degradation takes place.

2261 BIOSC 1500 SEC1030 Cell Bio 1500'25 first midterm, 75 min version

Lysosomes fuse with autophagosomes to form autolysosomes

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