Lou Gehrig and Stephen Hawking had different forms of Amyotrophic Lateral Sclerosis, which are associated with shorter and longer life-spans, respectively.

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The question states that Lou Gehrig and Stephen Hawking had different forms of Amyotrophic Lateral Sclerosis (ALS), which are associated with shorter and longer life-spans, respectively.
Option 1: True. This statement is accurate in a broad sense. ALS encompasses several forms and onset patterns (for example, bulbar vs. limb onset, and varying progression rates). Lou Gehrig’s ALS is historically described as having a relatively rapid progression leading to a shorter life expectancy, whereas Stephen Hawking’s course was notably slow and prolonged, resulting in a much longer survival than typical ALS cases. While individual courses vary, the general idea that different forms or presentations of ALS can be associated with different progression speeds and lifespans is supported by medical understanding of the disease.
Option 2: False. This choice would assert that the statement is incorrect. However, ALS is heterogeneous, and the literature recognizes that some phenotypes progress quickly while others progress slowly. The famous contrast between Gehrig’s rapid decline and Hawking’s unusually long survival illustrates that different disease forms or presentations can be linked to distinct life-spans, making this option inaccurate if taken as a blanket rule against variability. In short, claiming there is no association between form and lifespan ignores well-documented differences in progression among ALS patients.
Option 3: False. This would claim that there is only one form of ALS or that form has no bearing on progression or lifespan. Such a view overlooks the heterogeneity of ALS, where varying onset sites, rates of progression, genetic factors, and bulbar vs. limb involvement contribute to diverse trajectories, including shorter or longer survival in different individuals.
Option 4: False. This would imply ALS forms affect only motor symptoms without impacting overall prognosis. In reality, the phenotype and progression rate of ALS have direct implications for prognosis and lifespan, so stating that form doesn’t influence life expectancy would be inaccurate.

01:146:447:01 CLINICAL NEUROBIO CN F25 Exam 3

Lou Gehrig and Stephen Hawking had different forms of Amyotrophic Lateral Sclerosis, which are associated with shorter and longer life-spans, respectively.

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