题目

CHE 008B A01 SS1 2025 Lecture 9 - Reactions of Enolate Ions

匹配题

Put the mechanism steps in order for an aldol condensation. (Not all steps may be used) 1: First Mechanism Process 2: Second Mechanism Process 3: Third Mechanism Process

选项

A.Nucleophilic Acyl Addition

B.E2

C.Acid / Base

D.Electrophilic Aromatic Substitution

E.Nucleophilic Acyl Substitution

F.SN1

G.SN2

H.E1

I.E1-Conjugate Base

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标准答案

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思路分析

Here is a step-by-step analysis of the provided matching question and options to understand which elements fit the aldol condensation mechanism. First, I restate the task: we need to place mechanism steps in order for an aldol condensation, and the provided correct matches are listed as: Acid / Base, Nucleophilic Acyl Addition, and E1-Conjugate Base. Option by option analysis: - Nucleophilic Acyl Addition: This step describes the nucleophilic attack of an enolate (or other nucleophile) on a carbonyl group to form a tetrahedral intermediate. In the aldol mechanism, after deprotonation to form an enolate (base-catalyzed step), the enolate carbon attacks the carbonyl carbon of another aldehyde or ketone. This corresponds to the core nucleophilic addition event to a carbonyl, so labeling this as a key step in the aldol sequence is correct. - E2: This option represents a concerted bimole......Login to view full explanation