题目

CHE 008B A01 SS1 2025 Lecture 9 - Aldol Condensation Reagents

多重下拉选择题

Look at each of the given compounds and determine if they would be a nucleophile only, an electrophile only, both, or neither for an aldol condensation. Compound A: electrophile only Compound B: nucleophile only Compound C: both an electrophile and a nucleophile Compound D: neither Compound E: both an electrophile and a nucleophile Compound F: nucleophile only

查看解析

标准答案

Please login to view

思路分析

To tackle this question, recall how aldol condensations proceed in terms of electrophile and nucleophile roles. Key concepts to keep in mind: - Electrophile: the carbonyl carbon of an aldehyde or ketone is typically the electrophilic center that accepts nucleophilic attack. - Nucleophile: the enol or enolate form of a carbonyl compound (or another suitably acidic site) can attack an electrophile; in aldol chemistry, the enolate/enol acts as the nucleophile that attacks the carbonyl carbon of another molecule. - A molecule can sometimes act as both electrophile and nucleophile, depending on the reaction partner and whether an enolate/enol is formed at its alpha position. - A molecule that lacks an alpha-hydrogen (and cannot form an enolate/enol) generally behaves as an electrophile (it can be attacked) but not as a nucleoph......Login to view full explanation

登录即可查看完整答案

我们收录了全球超50000道考试原题与详细解析,现在登录,立即获得答案。

类似问题